EPIC Study design1
![36 centres](https://www.epictrial.com/assets/img/centrum.png)
centres
![360 dogs](https://www.epictrial.com/assets/img/poodle.png)
dogs
![Double-blinded Placebo-controlled](https://www.epictrial.com/assets/img/A-B-dogs.png)
double-blinded placebo-controlled
![11 countries](https://www.epictrial.com/assets/img/earth.png)
countries
![Over 5 years](https://www.epictrial.com/assets/img/calendar.png)
years
Building on the groundwork laid by the QUEST Study, EPIC is the largest prospective, randomised clinical study in veterinary cardiology (regarding both study time and total days in study).
- Led by independent cardiologists
- High-quality, robust dataset
- Comparable in size to many studies of human patients with cardiovascular disease
Epic study inclusion criteria
![Echocardiographic evidence of advanced MMVD](https://www.epictrial.com/assets/img/advenced-mmvd.png)
![Dogs 6 years of age or older](https://www.epictrial.com/assets/img/6years.png)
![Characteristic systolic heart murmur greater than or equal to grade 3/6](https://www.epictrial.com/assets/img/heart-murmur.png)
![Body weight between 4.1 kg and 15 kg](https://www.epictrial.com/assets/img/body-weight.png)
![Evidence of cardiac enlargement](https://www.epictrial.com/assets/img/cardiac-enlargement.png)